Gomisin J

Research use only, not for human use.

Gomisin J is a natural product and have vasodilatory activity.?Gomisin J suppresses lipid accumulation by regulating the expression of lipogenic and lipolytic enzymes and inflammatory molecules through activation of AMPK, LKB1 and Ca2+/calmodulin-dependent protein kinase II and inhibition of fetuin-A in HepG2 cells.

Gomisin J is a natural product and have vasodilatory activity.?Gomisin J suppresses lipid accumulation by regulating the expression of lipogenic and lipolytic enzymes and inflammatory molecules through activation of AMPK, LKB1 and Ca2+/calmodulin-dependent protein kinase II and inhibition of fetuin-A in HepG2 cells.Gomisin J attenuated lipid accumulation in OA-induced HepG2 cells.?It also suppressed the expression of lipogenic enzymes and inflammatory mediators and increased the expression of lipolytic enzymes in OA-induced HepG2 cells.?Furthermore, the use of specific inhibitors and fetuin-A siRNA and liver kinase B1 (LKB1) siRNA transfected cells demonstrated that gomisin J regulated lipogenesis and lipolysis via inhibition of fetuin-A and activation of an AMP-activated protein kinase (AMPK)-dependent pathway in HepG2 cells.

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Membrane Transporter/Ion Channel

AMPK

AMPK|Calcium Channel

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66280-25-9

388.46

C22H28O6

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (257.43 mM)

COc1c(O)cc2C[C@H](C)[C@H](C)Cc3cc(O)c(OC)c(OC)c3-c2c1OC

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(-20℃)

With Ice Pack

≥ 2 years